CONGLUTININ
CONGLUTININ: Conglutinin is a euglobulin of molecular weight of 750,000. It is heat stable. It is present in bovine serum. It acts as antibody to complement. It is not immunoglobulin and requires Ca +4′ for its activity. It reacts exclusively with bound C3. Conglutinin causes agglutination of sensitized sheep erythrocytes (conglutination) if they have combined with complement. The titres of serum 1K rise in condition e.g., infection and autoimmune disease.
Complement dependent serological tests are:
(1) Immune adherence test i.e., some bacteria react with specific antibody in the presence of complement, particulate material e.g. erythrocytes, platelets, and bacteria are aggregated and adhere to the cells e.g., Vibrio cholerae, Treponema pallidum.
(2) Complement fixation test.
(3) Conglutinating complement absorption.
(4) Immobilisation test e.g., Treponema pallidum.
(5) Cytolytic or cytocidal test e.g., Vibrio cholerae.
(6) Opsonization.
Tags: carcinomatosis, coronary occlusion, glomerulonephritis, malaria, nephrosis, Rheumatic Fever, serum sickness
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