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TYPHUS FEVER GROUP

Written by Dr.Chris

TYPHUS FEVER GROUP:
(a) Epidemic typhus: The disease has been reported from all parts of the world. In India it occurs in Kashmir (India).
The causative agent is Rickettsiae prowazekii. Man is the only natural vertebrate host. No extrahuman reservoir has been suggested.
Pediculus humanus corporis (human body louse) is the vector. Lice is infected by feeding rickettsiemic […]


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Antigenic structures: Pneumococcus

Written by Dr.Chris

Antigenic structures: Pneumococcus possesses a number of antigens.
(a) Nucleoprotein: It is neither species specific nor type specific. Antibody to this antigen is not protective.
(b) Species specific polysaccharides hapten: It is situated at the cell surface and is not related with capsular antigen.
(c) Capsular polysaccharide is found in capsulated form. It determines type specificity of organism and virulence. Pneumococci […]


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Physical Methods of Sterilization

Written by Dr.Chris

Physical Methods:
1. Sunlight: It possesses appreciable bacteriocidal activity. The action is due to ultraviolet rays. This is one of the natural methods of sterilization in case of water in tanks, river and lakes.
2. Drying: Drying in air has deleterious effect on many bacteria. Spores are unaffected by drying. Hence it is very unreliable method.
3. Heat: The factors influencing […]


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Sterilization and Disinfection

Written by Dr.Chris

Sterilization and Disinfection: The process of sterilization finds application in microbiology for ,prevention of contamination by extraneous organisms, in surgery for maintenance of asepsis, in food and drug manufacture for ensuring safety from contaminating organism and many other situation.
Sterilization: It is a process by which articles are freed of all micro-organisms both in vegetative or […]


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Selection of mutants

Written by Dr.Chris

Selection of mutants: In a patient’s body or in culture, a mutant will become sufficiently numerous to be observable and to produce significant effects only if its new character makes it better fitted to grow under prevailing conditions (in culture medium or host’s tissue) than parental bacteria and so enable it to outgrow an outnumber […]


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CONGLUTININ

Written by Dr.Chris

CONGLUTININ: Conglutinin is a euglobulin of molecular weight of 750,000. It is heat stable. It is present in bovine serum. It acts as antibody to complement. It is not immunoglobulin and requires Ca +4′ for its activity. It reacts exclusively with bound C3. Conglutinin causes agglutination of sensitized sheep erythrocytes (conglutination) if they have combined […]


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COMPLEMENT SYSTEM

Written by Dr.Chris

COMPLEMENT SYSTEM: Complement is well known for its ability to react with wide variety of antigen antibody combination to produce important physiological results. Included in this group of reaction are:
1. The destruction of erythrocytes as well as other tissue cells.
2. The initiation of inflammatory changes.
3. The lysis of bactereal cells.
4. Enhancement of phagocytosis involving some opsonized particles.
The complement refers […]


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