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Prevention and Control of Leprosy

Written by Dr.Chris

Leprosy is a chronic infectious and communicable disease. Many of patients with leprosy are having infectious (bacilliferous) type of the disease. This is the main source of infection. Seggregation of leprosy patients voluntarily or forcibly is one of the steps in control of the. disease. But it is a great task and often leads to […]


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Leprosy (Hansen’s disease)

Written by Dr.Chris

Leprosy (Hansen’s disease) is a chronic infectious disease caused by an acid fast bacillus called Mycobacterium leprae. These organisms are seen in clumps in tissue smears and are less acid fast and less alcohol fast than mycobacterium tuberculosis, the causative organism for tuberculosis. In vitro culture of the organism is still not successful; even though […]


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Predominant skin lesions

Written by D C Morgan

Migratory type of thrombophlebitis may sometimes be the manifestation of carcinoma of the head of the pancreas. In cystic fibrosis of the pancreas excess amounts of chlorides are excreted through sweat and estimation of chloride in sweat may help in its diagnosis. Acute haemorrhagic pancreatitis may be manifested as purpura or ecchymosis in the left […]


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SKIN IN SYSTEMIC DISEASES

Written by D C Morgan

Skin often mirrors the presence of an internal disease. A detailed dermatological examination often helps the physician to get some clues regarding the primary disease from which the patient is suffering.
Skin and gastrointestinal tract:- Most of the gastrointestinal diseases are associated with some form of skin lesions. In Peutz-Jeghers syndrome intestinal polyps are associated wtih […]


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Neurodermatitis

Written by D C Morgan

Neurodermatitis has already been discussed under eczemas. It is characterized by well circumscribed, intensely pruritic lichenified plaques on the feet or neck. Patient goes on scratching that particular site. This is an outlet for the emotional problems, the patient has. Pruritus ani and pruritus vulvae may be some times purely psychological origin.
Pleasure is achieved by […]


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Dermatomyositis

Written by D C Morgan

The first symptom noticed by most of the patients with dermatomyositis is difficulty to climb up steps. The proximal group of muscles of the limb; are affected first by the disease process. Tenderness of the muscle may be elicited in most cases.
Skin changes include diffuse erythema, inac.ulopapular eruptions and exfoliative dermatitis. Heliotropic pigmentation in the […]


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Treatment of acne

Written by D C Morgan

Acne is a chronic inflammatory disorder of pilosebaceous apparatus. At the time of puberty there is an increased level Of androgens in body. This androgen causes increase in size and activity of sebaceous glands. It further causes epithelialisation of-follicular orifices which leads to partial block in the follicular opening. This block and subsequent anoxia leads […]


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Merits and Demerits of Various in Vivo Tests

Written by D C Morgan

A positive skin test in itself does not indicate absolutely that the patient will develop systemic reaction upon receiving penicillin and a negative test does not mean that penicillin can be administered safely.
The possibility that routine skin testing with penicillin may itself lead to sensitisation is there. The scratch test though easy to perform is […]


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Infra Dermal (ID) Test

Written by D C Morgan

In Infra Dermal (ID) Test, 0.1 ml of the test solution of penicillin is injected intradermally on the forearm and mark the area with a skin pencil. Development of a flare and wheal at that site with in 15 to 20 minutes indicates sensitivity.
A patient on test dose, should not receive any corticosteroid or antihistamines […]


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Pencillin Sensitisation tests, Scratch Test

Written by D C Morgan

Sensitisation test: There are no reliable sensitisation tests which ca n infallibly predict the occurance of immediate type of reaction to a non protein drug nor is it safe to perform ID tests with suspected drugs as they may sometimes cause severe and even fatal anaphylaxis.
Potassium benzyl penicillin is an excellent antigenic substance which in […]


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Teratogenic effect, Hypersensitivity

Written by D C Morgan

Teratogenic effect: - Developmental defects may be produced in the foetus by administration of certain drugs especially between the 34th and 45th days of gestation. Methotrexate, tetracycline, corticosteroids, phenothiazines and thalidomides are the common teratogenic agents.
Hypersensitivity:- There are mainly four types of hypersensitivity reactions. They are: Type I Anaphylaxis Type II Cytotoxic Type III Arthus; […]


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Erytheme multiforme

Written by D C Morgan

Erytheme multiforme manifests as sudden eruption of different types of lesions-erythema, papules, nodules, plaques, vesicles and bullae. The lesions are distributed bilaterally on the flexor aspect of the distal part of limbs. The characteristic lesion seen in erythema multiforme is called ‘iris lesion’. It presents as an erythematous, round macule or plaque.
The central part of […]


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Toxic epidermal necrolysis

Written by D C Morgan

Toxic epidermal necrolysis is a severe condition characterized by sudden development of superficial blisters which join in a few hours, to form ’scald’ like skin lesions. The epidermis gets detached in sheets to leave large raw areas.
Drugs and staphylococcal toxins are the main causes of this often fatal condition. The patient will be highly toxic. […]


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Erythema nodosum

Written by D C Morgan

Erythema nodosum manifests as sudden eruption of erythematous painful and tender cutaneous nodules, bilaterally on the anterior aspect of the legs. Associated fever and arthralgia may be noted in most cases.
The lesion subsides in 7 to 14 days leaving faint hyperpignientation. It does not usually ulcerate except in leprosy. Common causes are streptococcal throat infection, […]


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Henoch - Schoenlein Purpura

Written by D C Morgan

Henoch - Schoenlein Purpura, also called anaphylactoid purpura, usually manifests as bilateral palpable purpuras (purpura on urticarial base) of extremities, more on legs associated with flitting joint pains or sometimes obvious hydrarthrosis and abdominal pain. Urine may show red blood cells and albumin.
The disease is essentially due to an allergic vasculitis and involves not only […]


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