MONOCLONAL ANTIBODIES
Written by Dr.ChrisMONOCLONAL ANTIBODIES: Hybridoma technology for the production of antibodies was introduced by Kohler and Milstein for which they have been awarded the Noble prize in Medicine 1984. Now it is possible to successfully generate not only mouse hybridomas but also interspecies (rat-mouse and human-mouse) hybridomas. Even human to human hybridomas have.been produced.
Monoclonal antibodies derived from […]
Tags: bacteremia, conjunctivae, hemolytic disease, inflammation, jaundice, Neonatorum, obstruction, severe sepsis and hemolysis
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IMMUNOLOGICAL TOLERANCE
Written by Dr.ChrisIMMUNOLOGICAL TOLERANCE: It is a kind of immunological unresponsiveness involving antibody production as well as cell mediated response. This non reactivity may be specific to the particular antigen only whereas immune reaction to other antigens remains unaffected. Tolerance can be induced for any of the substances that induce antibody production. It may be induced by […]
Tags: bacteremia, conjunctivae, hemolytic disease, inflammation, jaundice, Neonatorum, obstruction, severe sepsis and hemolysis
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TYPE III REACTIONS: HYPERSENSITIVITY
Written by Dr.ChrisTYPE III REACTIONS: Immune Complex Diseases:
Here the damage is caused by antigen antibody complex. This may precipitate on or around blood vessels causing damage to cells secondarily or on membrane interfering with their function. In antigen excess, soluble circulating complex may be formed with antibodies. These may be deposited on blood vessel walls or on […]
Tags: bacteremia, conjunctivae, hemolytic disease, inflammation, jaundice, Neonatorum, obstruction, severe sepsis and hemolysis
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TYPE II REACTIONS: HYPRSENSITIVITY
Written by Dr.ChrisTYPE II REACTIONS: Cytotoxic and Cytolytic:
The type of reaction is initiated by antibodies that react with either antigenic determinant of cell or tissue element. Cell damage occurs in presence of complement or mononuclear cells.
In sedormid purpura, sedormid (allyl isopropyl acetyluria) is ad-ministered. It combines with platelets altering their surface antigenecity. Antibodies are formed against sedormid […]
Tags: bacteremia, conjunctivae, hemolytic disease, inflammation, jaundice, Neonatorum, obstruction, severe sepsis and hemolysis
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Icterus neonatorum: Disease of Newborn
Written by Dr.ChrisIcterus neonatorum: A slight amount of jaundice is not infrequently seen in the newborn. It appears usually on the third or fourth day after delivery and generally within the first week. It is seen first on the trunk and face, then on the extremities and conjunctivae. In mild cases, the urine and feces remain normal […]
Tags: bacteremia, conjunctivae, hemolytic disease, inflammation, jaundice, Neonatorum, obstruction, severe sepsis and hemolysis
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Prevention of Asphyxia Neonatorum
Written by Dr.ChrisPrevention of Asphyxia Neonatorum:
The prevention of asphyxia prior to delivery is based on the recognition and avoidance of the causes. The obstetrician should, as far as possible, leave the delivery to normal forces and interfere only when really necessary. The injudicious use of analgesics (especially barbiturates and morphine), oxytocics and inhalation anesthetics causes grave harm, […]
Tags: asphyxia, auscultation, barbiturates, Meconium, morphine, Neonatorum, oxytocics
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